The phosphate salt of codeine occurs as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in water and slightly soluble in Liquor. The molecular weight is 406.37. Its molecular formula is C18H21NO3•H3PO4 • ½ H2O, and it has the following chemical framework.
Follow the Instructions on your own prescription label and browse all medication guides. In no way use this drugs in greater quantities, or for for a longer period than prescribed. Get this drugs only until finally your signs or symptoms distinct up.
Many of the studies, equally good and detrimental, had been minimal by small sample measurement, recall bias and absence of information pertaining to dose and timing of exposure.
Take this medication exactly as prescribed to decreased the risk of addiction. Question your medical doctor or pharmacist For additional details.
Promethazine is properly absorbed within the gastrointestinal tract. Clinical results are evident within twenty minutes following oral administration and generally previous 4 to 6 several hours, Despite the fact that They could persist given that twelve several hours.
Promethazine with Codeine Oral Alternative contains codeine, a Timetable V controlled material. As an opioid, Promethazine with Codeine Oral Remedy exposes users into the dangers of habit, abuse, and misuse [see Drug Abuse and Dependence ( nine)], which may lead to overdose and Dying [see Overdosage ( 10)]. Reserve Promethazine with Codeine Oral Solution for use in adult sufferers for whom the benefits of cough suppression are envisioned to outweigh the risks, and in whom an adequate assessment on the etiology of the cough has been designed. Assess Each and every affected person’s threat just before prescribing Promethazine with Codeine Oral Resolution, prescribe Promethazine with Codeine Oral Alternative with the shortest period that is definitely reliable with specific individual therapy objectives, watch all sufferers often for the development of dependancy or abuse, and refill only soon after reevaluation of the necessity for continued treatment.
If you're prescribed this medication on a regular routine and skip a dose, consider it as soon as you keep in mind. Whether it is close to the time of the subsequent dose, skip the missed dose. Consider your subsequent dose in the regular time. Do not double the dose to capture up.
Mainly because these reactions could possibly be claimed voluntarily from a inhabitants of uncertain dimension, It is far from constantly possible to reliably estimate their frequency or create a causal partnership to drug publicity.
If a affected individual demands a refill, reevaluate the reason for the cough and evaluate the necessity for ongoing procedure with Promethazine with Codeine Oral Solution, the relative incidence of adverse reactions, and the event of habit, abuse, or misuse.
Absorption Codeine is absorbed with the gastrointestinal tract with maximum plasma concentration taking place 60 minutes put up administration. The presence of a large-Excess fat, substantial-calorie meal did not considerably effect the PK of codeine.
Drug interactions may perhaps alter how your check here remedies perform or boost your danger for major Negative effects. This doc would not consist of all feasible drug interactions.
To lower the chance of dizziness and lightheadedness, stand up slowly but surely when rising from the sitting or lying posture.
Promethazine is metabolized from the liver to various inactive metabolites like sulfoxides of promethazine, N-demethylpromethazine together with other glucuronides.
If Promethazine with Codeine Oral Resolution is utilized for a chronic time period inside a pregnant female, recommend the client of the risk of neonatal opioid withdrawal syndrome and make sure that suitable therapy will probably be available [see Warnings and Safety measures (five.20)].